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Hypertension
New drug, similar to omapatrilat, impressive in hypertension
Mar 18, 2010 16:00 EDT
A new BP-lowering drug that acts in a similar way to omapatrilat—an agent that never quite made it to the market—has shown promise in a preliminary trial. Crucially, this dual inhibiting agent, named LCZ696, blocks angiotensin II rather than angiotensin-converting enzyme; there was no indication of angioedema in the study.
Featured news
Prevention
Death, CVD risk declines in people who "normalize" vitamin-D levels
4 COMMENTS - Mar 18, 2010 17:00 EDT
In a group of nearly 1000 subjects told they had low vitamin D at baseline, those who managed to up their levels over follow-up were significantly less likely to die or to suffer a combination of cardiovascular end points.
Heart failure
How to diurese in acute HF: Dosing strategies get an evidence base
Mar 17, 2010 11:00 EDT
Is it safe to start patients with acute decompensated heart failure on loop diuretics at higher-than-standard doses? And is it more effective to administer them in a continuous infusion or intermittent boluses? Until the DOSE trial asked those questions, IV diuretic strategies in ADHF had never or rarely been put to a randomized, controlled test.
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Editorial series
A series of discussions among editorial leaders, developed by theheart.org

The Cardiology Show
ACC 2010 Review from Atlanta: INVEST, ACCORD, EVEREST II, and NAVIGATOR
Mar 17, 2010 16:25 EDT
Dr Valentin Fuster sits down with Drs Peter Berger, Anne Curtis, Tim Gardner, Tony Gershlick, Harlan Krumholz, Darren McGuire, Ileana Piña, and Rita Redberg to discuss the lessons learned at the ACC 2010 Scientific Sessions, including why lower may not be better for blood pressure, why preventing diabetes does not necessarily reduce cardiovascular risk, and the future of the mitral-valve clip.
Editorial series
Informed consent, clinical research, and patient care
1 COMMENT - Mar 11, 2010 14:20 EST
Does informed consent protect patients or shield researchers? Join the debate with Dr Bob Harrington and his guests Drs Deepak Bhatt and Harvey White.
Editorial series
Women in cardiology: Is gender an issue?
5 COMMENTS - Mar 4, 2010 10:15 EST
Do gender perceptions affect the way female physicians are treated in cardiology? Drs Melissa Walton-Shirley, Judith Hochman, Suzanne Oparil, and Lynne Warner Stevenson tackle this important question.
Editorial series
Public smoking bans and cardiovascular health
15 COMMENTS - Feb 25, 2010 15:25 EST
Studies suggest public smoking bans reduce the incidence of acute MI. So why is America not smoke-free? Dr Melissa Walton-Shirley discusses this important issue with the AHA's Nancy Brown and Dr Clyde Yancy.
Imaging
FDA advisory panel votes unanimously in favor of Medtronic's MRI-safe pacemaker
Mar 19, 2010 17:32 EDT
Medtronic's REVO MRI stands to be the first pacemaker FDA-approved specficially for patients undergoing MRI scans, after FDA's Circulatory System Devices advisory panel voted unanimously in favor of recommending the agency approve it.
Medscape Medical News
Highest simvastatin dose linked to increased risk of muscle injury, FDA warns
Mar 19, 2010 15:45 EDT
Simvastatin 80 mg is associated with increased risk of myopathy compared with lower doses and other statins, according to an FDA review of clinical-trial and other data.
Brain/Kidney/Peripheral
Abnormal ABI an indicator of cardiovascular events in low-risk elderly
Mar 19, 2010 15:00 EDT
An abnormal ankle-brachial index can predict an increased risk for future cardiovascular events in elderly people with low to intermediate Framingham risk scores, according to results from a new study.
Hypertension
ACE inhibitor/ARBs still used in pregnancy despite teratogenicity
Mar 19, 2010 14:15 EDT
New research from the UK has found that doctors are still prescribing ACE inhibitors and angiotensin-receptor blockers in women of child-bearing age, despite evidence that they are teratogenic. Reasons include a lack of awareness of the issue among GPs and obstetricians and ambiguity in hypertension guidelines, says the researcher.
Arrhythmia/EP
Watchman delayed: FDA wants more data on the LAA-closure device before approving
Mar 19, 2010 11:15 EDT
Atritech, the maker of the Watchman device, announced that the FDA requested another study to provide more safety and effectiveness data before it will approve the LAA-closure device.
Arrhythmia/EP
Confusion persists over ICD/CRT-D recall, but hopes high for swift resolution
Mar 19, 2010 10:00 EDT
Industry analysts have been rabidly trying to get to the bottom of the company's action since Monday, polling physicians and company reps to understand the reason for the "retrieval" notice and doctor's reactions.
Heart failure
Broaden CRT indications to include mild heart failure, recommends FDA advisory panel
Mar 19, 2010 09:00 EDT
The panel unanimously recommended that cardiac resynchronization therapy indications be extended to include patients in NYHA functional class 1 or 2, with a few added twists aimed at excluding subgroups that are least likely to benefit from the device therapy.
Interventional/Surgery
JETSTENT: Improved reperfusion and short-term clinical end points with thrombectomy
Mar 18, 2010 17:15 EDT
The results lead researchers to conclude that thrombectomy should be routine in PCI for patients with an increased thrombus burden. Others aren't sure the data are sufficient to justify its routine use, however.
Features
MRI of implantable devices: Do we need safer devices, safer scanning procedures, or both?
Mar 18, 2010 14:30 EDT
The advent of new "MRI-safe" devices does not imply that MRI cannot be performed safely on older devices, according to the leaders of the MagnaSafe registry.
Medscape Medical News
Erectile dysfunction a red flag for mortality, cardiovascular events
Mar 17, 2010 13:45 EDT
New findings suggest erectile dysfunction is a marker for increased risk of death and heart attacks in men with heart disease.
Most popular
  1. PLATO CABG analysis confuses cardiologists
  2. Cardiologists voice concern on FDA clopidogrel warning
  3. Is triple antiplatelet therapy after PCI the way forward?
  4. Boston Scientific issues broad retrieval of ICDs, CRT-Ds, halts shipping of new devices
  5. How to diurese in acute HF: Dosing strategies get an evidence base
  6. Long-term, but small, PASSION and DEDICATION studies raise concern about DES in STEMI
  7. Warfarin genotyping reduces hospitalizations
  8. Optimal dual antiplatelet duration in REAL-LATE, ZEST-LATE: Too little, too soon
  9. Safely switch from amiodarone to dronedarone in two days, suggests analysis
  10. ACCORD: Fenofibrate no benefit to statin therapy in high-risk diabetic patients
View all news »
  1. ACCORD: Fenofibrate no benefit to statin therapy in high-risk diabetic patients
  2. ACCORD BP: Intensive BP lowering futile in diabetics
  3. NAVIGATOR off course to diabetes prevention with valsartan, nateglinide
  4. Clopidogrel receives boxed warning for reduced benefit in poor metabolizers
  5. PLATO CABG analysis confuses cardiologists
  6. EVEREST II: Mitral-clip device noninferior to surgical repair or replacement
  7. Death, CVD risk declines in people who "normalize" vitamin-D levels
  8. Optimal dual antiplatelet duration in REAL-LATE, ZEST-LATE: Too little, too soon
  9. Boston Scientific issues broad retrieval of ICDs, CRT-Ds, halts shipping of new devices
  10. Cardiologists voice concern on FDA clopidogrel warning
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Also on theheart.org
Editorial series
Technology and the future of cardiovascular care
3 COMMENTS - Feb 4, 2010 15:00 EST
Dr Eric Topol talks to heartwire's Shelley Wood about remote monitoring, individualized medicine, and the changing face of cardiovascular care.
Features
Ripe for change: US ponders populationwide salt-reduction policies
19 COMMENTS - Jan 29, 2010 14:15 EST
Messages to limit the amount of salt added to food have had little impact on sodium intake in the West, where more than 75% of salt in the diet there is contained in readily prepared foods. The UK has recently gotten tough with the food industry and cut salt intake by 10%; is it time the US and others took a similar stance? heartwire examines the issues.